The Horowitz MSIDS Questionnaire

Answer the following questions as honestly as possible. Think about how you have been feeling over the previous month and how often you have been bothered by any of the following problems. Score the occurrence and frequency of each symptom on the following scale: never, sometimes, most of the time, all of the time or not applicable.

Section 1: SYMPTOM FREQUENCY SCORE Give yourself the score of 0-3 depending on the frequency of your condition. Symptoms Never (0) Sometimes (1) Most of the Time (2) All the Time (3) Unexplained fevers, sweats, chills, or flushing Unexplained weight change; loss or gain Fatigue, tiredness Unexplained hair loss Swollen glands Sore throat Testicular or pelvic pain Unexplained menstrual irregularity Unexplained breast milk production; breast pain Irritable bladder or bladder dysfunction Sexual dysfunction or loss of libido Upset stomach Change in bowel function (constipation or diarrhea) Chest pain or rib soreness Shortness of breath or cough Heart palpitations, pulse skips, heart block History of a heart murmur or valve prolapse Joint pain or swelling Stiffness of the neck or back Muscle pain or cramps Twitching of the face or other muscles
 Headaches Neck cracks or neck stiffness Tingling, numbness, burning, or stabbing sensations Facial paralysis (Bell’s palsy) Eyes/vision: double, blurry Ears/hearing: buzzing, ringing, ear pain Increased motion sickness, vertigo Lightheadedness, poor balance, difficulty walking Tremors Confusion, difficulty thinking Difficulty with concentration or reading Forgetfulness, poor short-term memory Disorientation: getting lost; going to wrong places Difficulty with speech or writing Mood swings, irritability, depression Disturbed sleep: too much, too little, early awakening Exaggerated symptoms or worse hangover from alcohol Totals: Section 1 Score: Section 2: MOST COMMON LYME SYMPTOMS SCORE If you rated a 3 for all of the following symptoms in section 1, give yourself an additional 5 points: Fatique Forgetfulness, poor short-term memory Tingling, numbness, burning or stabbing sensations Distrubed sleep: too much, too little, early awakening Section 2 Score: Section 3: LYME INCIDENCE SCORE Now please circle the points for each of the following statements you can agree with: 1. You have had a tick bite with no rash or flulike symptoms. 3 points 2. You have had a tick bite, an erythema migrans, or an undefined rash,
followed by flulike symptoms. 5 points 3. You live in what is considered a Lyme-endemic area. 2 points 4. You have a family member who has been diagnosed with Lyme and/or
other tick-borne infections. 1 point 5. You experience migratory muscle pain. 4 points 6. You experience migratory joint pain. 4 points 7. You experience tingling/burning/numbness that migrates and/or comes
and goes. 4 points 8. You have received a prior diagnosis of chronic fatigue syndrome or
fibromyalgia. 3 points 9. You have received a prior diagnosis of a specific autoimmune disorder (lupus,
MS, or rheumatoid arthritis), or of a nonspecific autoimmune disorder. 3 points 10. You have had a positive Lyme test, such as an immunofluorescent assay (IFA), ELISA, Western blot, PCR, lymphocyte transformation tests (LTT and/
or ELISPOT) and/or Borrelia culture). 5 points Section 3 Score: Section 4: OVERALL HEALTH SCORE 1. Thinking about your overall physical health, for how many of the past thirty days was your physical health not good? _______Days Award yourself the following points based on the total number of days:
0–5 days = 1 point
6–12 days = 2 points
13–20 days = 3 points
21–30 days = 4 points 2. Thinking about your overall mental health, for how many days during the past thirty days was your mental health not good? _____Days
Award yourself the following points based on the total number of days:
0–5 days = 1 point 6–12 days = 2 points 13–20 days = 3 points 21–30 days = 4 points Score: Section 4 Score: Record your total scores for each section below and add them together to achieve your Health Score – Section 1 Score: Section 2 Score: Section 3 Score: Section 4 Score:

Empirical Validation of the Horowitz Multiple Systemic Infectious Disease Syndrome Questionnaire for Suspected Lyme Disease

Lyme disease is spreading worldwide, with multiple Borrelia species causing a broad range of clinical symptoms mimicking other illnesses. Serological laboratory tests for Lyme are known to be insensitive and unreliable, due to the bacteria’s ability to avoid immune recognition. A validated screening questionnaire would be clinically useful for both providers and patients. Three studies evaluated the Horowitz Multiple Systemic Infectious Disease Syndrome (MSIDS) Questionnaire (HMQ). Study 1, examined factor analysis and the psychometric properties of the questionnaire (reliability, construct, divergent and predictive validity) among 537 individuals being treated for Lyme disease. Study 2 involved an online sample of 1142 participants, who self-identified as either healthy (N=360) or suffering from Lyme now (N=782) and who completed the HMQ along with an outdoor activity survey. We examined convergent validity among the components of the scale and evaluated discriminant validity with the Big 5 personality characteristics. The third study compared the patient sample from Study 1 with an online sample of 637 healthy individuals. The purpose was to see if the questionnaire could accurately distinguish between Lyme patients and healthy individuals. Factor analysis results identified six underlying latent dimensions; four of these overlapped with critical symptoms identified by Horowitz—Neuropathy, Cognitive Dysfunction, Muscular/Skeletal Pain, and Fatigue. The HMQ showed acceptable levels of internal reliability using Cronbach’s Coefficient alpha. HMQ scores exhibited evidence of convergent and divergent validity. Components of the HMQ correlated more highly with each other than with unrelated traits. The results consistently demonstrated that the HMQ accurately differentiated those with Lyme disease from healthy individuals. The results support the use of the HMQ as a valid, efficient screening tool for medical practitioners and as an aid to individuals that may need to seek treatment.